Identification of the UGT isozyme involved in senecionine glucuronidation in human liver microsomes
نویسندگان
چکیده
The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201210, China (Y.-Q. H, B.-F. Z, Li Y., A.-Z. X, L.-L. X., C.-H. W., Z.-T. W.); Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Dalian, 116023, China (Y. L., Ling Y. H.-X. L.); Affilated Longhua Hospital of Shanghai University of Traditional Chinese Medicine, 725 South Wan-Ping Road, Shanghai, 200032, China (Y.-L. L.). DMD Fast Forward. Published on January 7, 2010 as doi:10.1124/dmd.109.030460
منابع مشابه
Identification of the UDP-glucuronosyltransferase isozyme involved in senecionine glucuronidation in human liver microsomes.
Senecionine (SEN) is a representative of the hepatotoxic pyrrolizidine alkaloids. Although phase I metabolism for cytochrome P450-mediated metabolic activation of SEN was investigated extensively, phase II metabolism for glucuronidation of this compound has not been investigated until now. In our present study, one unique glucuronidation product of SEN in human liver microsomes (HLMs) was ident...
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